Therapeutically classification: Antibiotic
Composition: Each 10 g syringe contains:
Oily Base q.s.
Target species: Dry cows
Endmast® is used for treatment and control of mastitis in dairy cows during the dry period.
Mechanism of action:
Cloxacillin is beta-lactamase resistant penicillin that, like other beta-lactam drugs, by binding to penicillin-binding protein (PBP), inhibits the trans-peptidases and prevents the construction of the bacterial cell wall peptidoglycan and causes destruction of the bacterial cell wall. Sulfadimidine sodium by competing with PABA, inhibits folic acid and, as a result, interrupts the synthesis of bacterial protein, therefore it is bacteriostatic. Trimethoprim acts by interfering with bacterial dihydrofolate reductase enzyme that builds tetrahydrofolic acid, an essential cofactor in the production of thymidine and DNA. Bacteria producing folic acid are sensitive to these drugs, so this medication stops their proliferation.
Dosage & Administration:
Clean and disinfect the teat, then infuse one syringe into each quarter at the last lactating. Massage the medication up into the milk cistern.
Milk: 4 days after parturition
Meat: 28 days after the last treatment
Do not use this product 30 days before of calving.
Do not use in lactating cows.
Shake well before use.
Allergic reaction to penicillin may occur in some animals.
Keep out of reach and sight of children.
Use only under the prescription of a veterinarian.
Do not store above 25 °C, keep away from light and freezing.
20×10 g syringes in a box
For veterinary use only