Sterile injectable solution
Therapeutically classification: Internal and external anti-parasite
Composition: Each ml contains:
Ivermectin 10 mg
Target species: Horses, Camels, Cattle, Sheep, Dogs and Cats
Ivermectin is a broad-spectrum anti-parasitic agent. It is indicated for the treatment and control of internal and external parasites in different species as:
Cattle and Sheep:
Gastrointestinal nematode species: Ostertagia spp., Haemonchus spp., Cooperia spp., Nematodirus spp., Trichostrongylus spp., Bunostomum spp., Trichuris spp., Strongyloides spp., Oesophagostomum spp. and Chabertia ovina
Lung worms: Dictyocaulus spp.
Mites: Sarcoptes bovis and Psoroptes ovis
Sucking lice: Linognathus vituli, L. pedalis, and Hematopinus eurysternus
Oestrid larvae: Hypoderma bovis, Hypoderma lineatum and Oestrus ovis
Horses: Parascaris equorum, Oxyuris equi, Draschia megastoma, trichostrongylus axei, Large and small Strongyles, Microfiller of Onchocerca spp., Habronema spp. and Gasterophilus spp.
Camels: Nematodes and mange mites
Dogs: Heartworm (prevention and treatment), mites, nematodes, roundworms, hookworms and whipworms
Cats: Ear mites, fleas and hookworms
Mechanism of action:
Ivermectin is a class of macrocyclic lactone anthelmintic that enhances the release of GABA at presynaptic neurons. GABA acts as an inhibitory neurotransmitter and blocks the post-synaptic stimulation of the adjacent neuron in nematodes or the muscle fibers in arthropods. By stimulating the release of GABA and or producing a slow and irreversible increase in permeability of glutamate-gated chloride channels (GluCl) to chloride ions and hyperpolarization of nerve cells, doramectin causes flaccid paralysis of the parasite and eventual death. Tapeworms (Cestoda) and flatworms (Trematoda) (such as Fasciola species) do not use GABA as a chemical mediator in peripheral nerves, so this drug has no effect on these parasites.
Dosage and Administration:
The drug dosage is 200 μg/kg B.W. or 0.5 ml/25 kg B.W.
Horses: By IM administration only.
Cattle, Camels and Sheep: By SC administration.
Dogs and Cats: By SC administration in loose skin in front of or behind of the shoulder.
For prevention of heartworm in dogs, 6 µg/kg B.W., monthly by SC administration.
Meat: 21 days after the last treatment
Milk: 28 days after the last treatment
Do not administer intravenously.
Do not use in foals less than 4 months old.
Do not use in animals less than 6 weeks old.
Use in Collie-breeds with caution and less than routine dose and observe this breed for at least 8 hours after administration.
Dispose of unused products and containers by incineration or in approved-landfills. Ivermectin may adversely affect fish or other waterborne organisms if disposed in water.
Do not administer with drugs that could potentially increase the penetration of ivermectin across the blood–brain barrier. Such drugs include ketoconazole, itraconazole, cyclosporine and calcium-channel blockers.
Keep out of reach and sight of children.
Use only under the prescription of a veterinarian.
In use stability:
21 days after first needle insertion
Do not store above 25°C, keep away from light and freezing.
50 ml vial in a box
For veterinary use only