Baycosin® 30%

Sterile Injectable Solution

Therapeutically classification: Antibiotic

Composition: Each ml contains:

Tilmicosin

300

Target species: Cattle, Calves and Sheep

Indications:

Baycosin^® 30% is used for treatment of bovine respiratory disease (BRD) caused by Mannheimia haemolytica or Pasteurella multocida, pneumonia associated with Pasteurella spp. in calves, cattle and sheep, acute mastitis caused by Staphylococcus spp. or Mycoplasma in sheep, abortion caused by Chlamydia spp. and foot rot caused by Fusobacterium necrophorum.

Mechanism of action:

Tilmicosin is a broad-spectrum semi-synthetic antibiotic from the class of macrolides. It has an antibacterial spectrum that is predominantly effective against Mycoplasma spp., Pasteurella spp. and Haemophilus spp. and various gram-positive organisms like Staphylococcus spp. It inhibits bacterial protein synthesis and prevents its growth. Cross-resistance between tilmicosin and other macrolide antibiotics has been observed.

Pharmacokinetics:

Respectively, 1 and 8 hours after SC injection of 10 mg/kg B.W. in cattle and sheep, maximum plasma concentration of drug is achieved. Following SC injection, tilmicosin is distributed throughout the body but especially high levels are found in the lungs. Lung concentrations of tilmicosin is remained above 90% of minimum inhibitory concentration (MIC) of Mannheimia haemolytica for a minimum of 4 days. Tilmicosin is excreted mainly via the bile into the faeces, with a small proportion being excreted via the urine.

Dosage & Administration:

10 mg/kg B.W. (1 ml/ 30 kg B.W.), single dose, only by SC injection in a skinfold of shoulder or over the rib cage behind the shoulder.

Withdrawal time:

Meat: 28 days after the last treatment.

Contra-indications:

Avoid IV or IM injection.

Do not administer to equine and goats.

Do not use in cattle that produce milk for human consumption.

Do not use in lambs under 15 kg B.W., and calves which are fed only by milk.

Do not use automatic syringe.

Caution:

Keep out of reach and sight of children.