Helmiclozol®

Oral Suspension

Therapeutically classification: Anthelmintic

Composition: Each ml contains:

Mebendazole	75	mg
Closantel (sodium)	50	mg

Target Species: Sheep and Lambs

Indications:

Helmiclozol^® can be used for control and treatment diseases caused by:

Nematodes:

Lung worms: dictyocaulus filarial

Stomach worms: Trichostrongylus axei; Ostertagias spp., Haemonchus contortus Intestinal worms: Nematodirus spp., Trichostrongylus spp., Cooperia spp., Strongyloides papillosus, Bunostomum spp., Chabertia ovina and Oesophagostomum spp.

Trematodes: Fasciola hepatica and Fasciola gigantia

Cestodes: Moniezia expansa and Avitellina centripunctata

Arthropods: Oestrus ovis.

This combination can be used in pregnancy and mating period.

Mechanism of action:

By penetrating the mitochondrial membrane, closantel prevents oxidative phosphorylation and transport of electrons and prevents the formation of ATP, thus causing the death of the parasite due to a sever change in its metabolism.

Mebendazole produces degeneration of the parasite microtubule and as a result, by inhibiting the uptake of glucose by the parasite it causes a decrease in energy storage, eventually resulting in death of parasite.

Dosage & Administration:

15 mg mebendazole and 10 mg closantel per Kg body weight or 1 ml of suspention per 5 Kg of body weight as an oral drench.

Withdrawal time:

Meat: 28 days after the last treatment

Milk: 28 days after the last treatment

Contraindications:

Do not use with chlorinated compounds (pesticide) because of the poisoning.

Caution:

Shake well before use.

Should be used within 30 days after opening the seal

In case of skin contact, immediately wash thoroughly with water.

Keep out of reach and sight of children