Bay Dorectin®

Sterile injectable solution

Therapeutically classification: Antiparasite

Composition: Each ml contains:

Doramectin

Target species: Cattle and Sheep

Indications:

Cattle: For treatment of:

Gastrointestinal roundworms (adults and fourth stage larvae): Ostertagia ostertagi (inc. inhibited larvae), Haemonchus placei, Trichostrongylus axei, Cooperia oncophora, Cooperia punctate, Bunostomum phlebotomum, Oesophagostomum radiatum and Trichuris spp.

Lungworms (adults and fourth stage larvae): Dictyocaulus viviparus

Eyeworms (adults): Thelazia spp.

Warbles (parasitic stages): Hypoderma bovis and Hypoderma lineatum

Biting lice: Damalinia (Bovicola) bovis

Sucking lice: Haematopinus eurystemus, Linognathus vituli and Solenopotes capillatus

Mange mites: Psoroptes bovis, Sarcoptes scabiei and Chorioptes bovis

Horn fly: Haematobia irritans

Sheep: For treatment of:

Gastrointestinal roundworms (Adults and fourth stage larvae (L4) unless otherwise indicated):

Chabertia ovina (adults only), Cooperia oncophora, Haemonchus contortus, Nematodirus battus (L4 only)^,Ostertagia (Teladorsagia) circumcincta, Strongyloides papillosus, Trichostrongylus axei, Trichostrongylus vitrines and Trichuris spp (Adults only)

Mange mites: Psoroptes ovis

Lungworms: Dictyocaulus filaria (Adults only)

Nasal bots (1st, 2nd and 3rd instar larvae): Oestrus ovis

Mechanism of action:

Doramectin is a class of macrocyclic lactone anthelmintic that enhances the release of GABA at presynaptic neurons. GABA acts as an inhibitory neurotransmitter and blocks the post-synaptic stimulation of the adjacent neuron in nematodes or the muscle fibers in arthropods. By stimulating the release of GABA and or producing a slow and irreversible increase in permeability of glutamate-gated chloride channels (GluCl) to chloride ions and hyperpolarization of nerve cells, doramectin causes flaccid paralysis of the parasite and eventual death. Tapeworms (Cestoda) and flatworms (Trematoda) (such as Fasciola species) do not use GABA as a chemical mediator in peripheral nerves, so this drug has no effect on these parasites.

Dosage & Administration:

Cattle: A single treatment of 1 ml (10 mg) /50 kg B.W. equivalent to 200 µg/kg B.W. by SC injection in the region of the neck

Sheep: A single treatment of 1 ml (10 mg) /33 kg B.W. equivalent to 300 µg/kg B.W. by IM injection for the treatment and control of Psoroptes ovis (sheep scab mite) and adult Nematodirus battus. In addition, adequate biosecurity measures should be implemented to prevent re-infestation. Ensure that all sheep which have been in contact with infested sheep are treated. After treatment, contact between treated infected and untreated uninfected flocks must be avoided for at least 14 days.

A single treatment of 1 ml (10 mg)/50 kg B.W. equivalent to 200 µg/kg B.W. by IM injection for the control of certain other gastrointestinal nematodes and nasal bots

Withdrawal time:

Meat: 70 days after the last treatment

Contra-indications:

Do not use in livestock that produce milk for human consumption.

Doramectin is very toxic to aquatic organisms and may accumulate in sediments.

Caution:

Do not eat, drink or smoke when using this product.

After using the drug, wash your hands.

Keep out of reach and sight of children.

Use only under the prescription of a veterinarian.

Storage:

Do not store above 25 °C, keep away from light and freezing.