Penikanix ^®

Penicillin G procaine + Kanamycin (Acid Sulfate)

Sterile powder for injectable suspension

Therapeutically classification: Antibiotic

Composition: Each vial contains:

Penicillin G Procaine	2000000	IU
Kanamycin (Acid Sulfate)	2	g

Target species: Cattle, Horses, Sheep, Goats, Cats and Dogs

Pharmacology:

Penicillins are an antibiotic of the ß-lactam class and kanamycin belongs to the aminoglycosides. Penicillins act by interfering with the formation of the bacteria’s cell wall while it is growing. This weakens the cell wall and kills the bacteria. Penicillin G is active against many gram-positive and a limited number of gram-negative bacteria. Aminoglycosides display bactericidal activity against most gram-negative bacteria, but not against gram-negative anaerobes and most gram-positive bacteria. These activities are attributed to a primary mode of action as protein synthesis inhibitors. The combination of penicillin G procaine and Kanamycin acts synergistic. It is active against both gram-positive and gram-negative bacteria.

Indication:

Penikanix^® is for treatment of infections caused by bacteria sensitive to Penicillin or Kanamycin such as gastrointestinal infections, respiratory tract infections; listeriosis, mastitis, urogenital tract infection; anthrax, tetanus, malignant edema, botulism, strangles, gas gangrene, foot rot, omphalitis, arthritis, meningitis, actinomycosis, leptospirosis, salmonellosis, preoperative treatments, the control of the secondary bacterial invaders in disease of primary viral origin.

Dosage & Administration:

Add 10-15 ml sterile WFI and shake well and use deep intramuscular injections.

Cattle & horses: 3000-10000 I.U penicillin G procaine & 3-10 mg kanamycin per kg of body weight, every 24 hours.

Sheep & goats: 5000-10000 I.U penicillin G procaine & 5-10 mg kanamycin per kg of body weight, every 24 hours

Cats & dogs: 10000-20000 I.U penicillin G procaine & 10-20 mg kanamycin per kg of body weight, every 24 hours

Contra-indications:

Do not use in animals with hypersensitivity to Penicillin G Procaine and/or aminoglycosides.

Do not administer in animals with a serious impaired renal and hepatic function.

Do not administer concurrently with tetracyclines, chloramphenicol, macrolides, lincosamides and furosemide.

Caution:

Never use IV and SC injection.

Epinephrine and antihistamines should be used immediately in case hypersensitivity to penicillins.

Because of the possibility of procaine positive doping test, do not use procaine penicillin G, 2 weeks before racing.

Keep out of reach and sight of children.

Use only under the prescription of veterinarian.

Withdrawal time:

Milk: 3 days after the last treatment

Meat: 10 days after the last treatment

Storage:

Do not store above 25 °C, keep away from light and moisture.

Packing:

25×20 ml flip off-capped vials in a box.

For veterinary use only