Sterile Injectable Solution
Therapeutically classification: Antibiotic
Composition: Each ml contains:
|Spectinomycin (sulphate tetrahydrate)||100||mg|
Target species: Sheep, Goats, Sucking calves, Dogs and Cats
Sheep and goats: Treatment of primary and secondary infections of respiratory tract due to mycoplasma and organisms susceptible to lincomycin and spectinomycin, pneumonia, infectious pleuropneumonia, foot rot due to Bacteroides nodosus and agalaxia.
Suckling calves (Before start of rumination): Treatment of respiratory-digestive trac infections (pneumo-enteritis) due to microorganisms susceptible to this drug.
Dogs: treatment of respiratory, dermal, urogenital and secondary bacterial infections.
Cats: treatment of urinary and upper respiratory tract infections, local dermal infections and secondary bacterial infections.
Mechanism of action:
Lincomycin is a bacteriostatic antibiotic and belongs to lincosamides group that binds to 50S ribosomal subunit, and inhibits protein synthesis. Spectinomycin is a bactericidal antibiotic and belongs to aminosyclitol that binds to 30S ribosomal subunit and helps to lincomycin for blockage of protein synthesis. Thereby, they affected on gram-positive and gram-negative bacteria and also Mycoplasma spp.
The peak of serum level for lincomycin is achieved 4-6 hours after injection. It is widely distributed in body and its concentration in most tissues such as bones reaches to a suitable level. The highest concentration is achieved in kidneys and liver. The lowest concentration is detectable in cerebro-spinal fluid (CSF). Lincomycin is metabolized in the liver and excreted via bile (Faeces) and urine. Spectinomycin is well absorbed after injection and reaches its maximum plasma concentration within one hour. It does not enter eyes and CSF and its molecular ability for protein binding is low. It excreted into urine via glomerular infiltration without any change.
Dosage & Administration:
Sheep and Goats: 1 ml per 10 kg B.W. by intramuscular injection once a day for 3 consecutive days.
Suckling calves: 1 ml per 10 kg B.W. by intramuscular injection twice in first day and once daily for 2-4 consecutive days.
Dogs and Cats: 1 ml per 5 kg B.W. by intramuscular injection each 12 or 24 hours for 12 days.
Meat: 14 days after the last treatment
Lincomycin is incompatible with novobiocin and kanamycin sulphate.
Lincomycin precipitates if used simultaneously with benzyl penicillin and phenytoin sodium.
Macrolides and chloramphenicol have antagonistic effect with lincosamides and should not be used simultaneously.
Do not use in cattle that produce milk for human consumption.
Do not administer to animals hypersensitive to lincomycin or/and spectinomycin.
Do not administer to animals with blood disturbances or sever impaired liver function.
Do not use in non-target animals like rabbits, guinea pigs, hamsters, horses and cattle with an active rumen and intestinal microbial flora because of digestive complications.
Use of this drug in solipeds may cause colitis.
In some cases, it may cause transient diarrhea in sheep and goats.
Sometimes, reduction of appetite and milk quantity is reported in goats.
In very rare cases, abortion or death of pregnant sheep which treated at last third period of pregnancy, has been reported.
Keep out of reach and sight of children.
Use only under the prescription of a veterinarian.
Do not store above 25°C, keep away from light and freezing.
In use stability:
21 days after first needle insertion
50 ml vial in a box
For veterinary use only
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