Helmiclozol^®

Oral Suspension

Therapeutically classification: Anthelmintic

Composition: Each ml contains:

Mebendazole	75	mg
Closantel (sodium)	50	mg

Target Species: Sheep and Lambs

Indications:

Helmiclozol^® can be used to control and treat diseases caused by:

Nematodes: (Lung worms: dictyocaulus filaria; Stomach worms: Haemonchus contortus, Ostertagias spp., Trichostrongylus axei; Intestinal worms: Nematodirus spp., Trichostrongylus spp., Cooperia spp., Sreongylus papillosus, Bunostomum spp., Chabertia ovina and Oesophagostomum spp.); Trematodes: Fasciola hepatica and Fasciola gigantia; Cestodes: Moniezia expansa and Avitellina centripunctata; Arthropods: Oestrus ovis.

This combination can be used in pregnancy and mating period.

Mechanism of action:

The mode of action of closantel is inhibiting oxidative phosphorylation in a parasite. A specific action of the drug is to stimulate ATP enzyme this resulting in the uncoupling of electron transport-associated phosphorylation.

This, in turn, causes change in energy metabolism in the parasite and, as a result, its death. Mebendazole produces degeneration of the parasite microtubule and block glucose uptake in parasite. Inhibition of glucose uptake causes depletion of energy store in parasite, eventually resulting in death.

Dosage & Administration:

15 mg mebendazole and 10 mg closantel per Kg body weight or 1 ml Helmiclozol^® per 5 Kg of body weight as an oral drench.

Withdrawal time:

Meat: 28 days after the last treatment

Milk: 28 days after the last treatment

Contraindications:

Do not use with chlorinated compounds (pesticide) because of the poisoning.

Caution:

Shake well before use.

Should be used within 30 days after opening the seal

In case of skin contact, immediately wash thoroughly with water.

Keep out of reach and sight of children

Use only under the prescription of veterinarian.

Storage:

Do not store above 25 °C, keep away from light and freezing.

Packing:

1 L HDPE bottle in a box

For veterinary use only