Endmast^® DC

Intramammary infusion

Therapeutically classification: Antibiotic

Composition: Each 10 g syringe contains:

Cloxacillin (benzathine)	500	mg
Sulfadimidine (sodium)	750	mg
Trimethoprim	125	mg
Oily Base q.s.	10	g

Target species: Dry cows

Indications:

Endmast^® is used for treatment and control of mastitis in dairy cows during the dry period.

Mechanism of action:

Cloxacillin is beta-lactamase resistant penicillin that like other beta-lactam drugs by binding to penicillin-binding protein (PBP) inhibits the trans-peptidases and prevents the construction of the bacterial cell wall peptidoglycan and causes destruction of the bacterial cell wall. Sulfadimidine sodium by competing with PABA, inhibits folic acid and as a result interrupts the synthesis of bacterial protein, therefore it is bacteriostatic. Trimethoprim acts by interfering with bacterial dihydrofolate reductase enzyme that builds tetrahydrofolic acid, essential cofactor in the production of thymidine and DNA. Bacteria producing folic acid, are sensitive to these drugs, so this medication stops their proliferation.

Dosage & Administration:

Clean and disinfect the teat, then infuse one syringe into each quarter at the last lactating. Massage the medication up into the milk cistern.

Withdrawal time:

Milk: 4 days after parturition

Meat: 28 days after the last treatment

Contra-indications:

Not to be used within 30 days of calving.

Do not use in lactating cows.

Caution:

Shake well before use.

Allergic reaction to penicillin may occur in some animals.

Keep out of reach and sight of children.

Use only under the prescription of a veterinarian.

Storage:

Do not store above 25 °C, keep away from light and freezing.

Packing:

20×10 g syringes in a box

For veterinary use only