Dexamast^®MC

Intramammary infusion

Therapeutically classification: Antibiotic and steroidal anti-inflammatory

Composition: Each 10 g syringe contains:

Penicillin G procaine	300,000	I.U
Dihydrostreptomycin (sulfate)	300	mg
Dexamethasone	1.5	mg
Oily base q.s.	10	g

Target species: Lactating cows

Indications:

Dexamast^® is used for treatment and control of mastitis in dairy cows during lactating period.

Mechanism of action:

Like other beta-lactam antibiotics, penicillin G procaine prevents the formation of the cell wall of susceptible gram-positive bacteria by interfering with the final stage of peptidoglycan synthesis. Beta-lactam antibiotics inhibit the activity of transpeptidase enzymes, which catalysis cross-linkage of the glycolpeptide polymer units that form the cell wall. They exert a bactericidal action but cause lysis only on growing bacteria. Dihydrostreptomycin is an aminoglycoside antibiotic with activity against gram-negative aerobes. After penetration to the cell envelope, it binds to receptors on the 30S subunit of the bacterial ribosome, induces misreading of the genetic code on the messenger ribonucleic acid (mRNA) template and causes bactericidal effect. Aminoglycosides exert synergistic action in combination with beta-lactam antibiotics. Dexamethasone is a potent corticosteroid which characterized by a high degree of anti-inflammatory and anti-allergic activity. Dexamast^® is active against numerous gram-positive and gram-negative pathogens which most commonly cause mastitis such as Staphylococcus spp., Streptococcus spp., Pasteurella spp., Salmonella spp., Actinobacillus spp., Escherichia coli, Clostridium spp., Leptospira spp., Proteus spp., Corynebacterium spp., Campylobacter spp. and etc.

Dosage & Administration:

Clean and disinfect the teat, then infuse one syringe into each quarter at the last lactating. Massage the medication up into the milk cistern. If necessary, be repeated within 12 hours (up to 3 times).

Withdrawal time:

Milk: 3 days after the last treatment

Meat: 7 days after the last treatment

Contra-indications:

Do not use in dry cows.

Caution:

Shake well before use.

Allergic reaction to penicillin may occur in some animals.

Use only under the prescription of a veterinarian.

Keep out of reach and sight of children.

Storage:

Do not store above 25°C, keep away from light and freezing.

Packing:

20×10 g syringes in a box

For veterinary use only