Closantel + Ivermectin

Injectable solution

Therapeutically classification: Antiparasite

Composition: each ml contains:

Closantel (sodium)        125 mg

Ivermectin                     5 mg

Target species: Cattle and Sheep

Indications:

Bay Clomectin^® is used for treatment of mixed trematode (fluke), nematode or arthropod infestations due to the following gastrointestinal roundworms, lungworms, eyeworms, warbles, mites and lice:

Trematodes (liver fluke): Fasciola hepatica and Fasciola gigantica

Gastrointestinal nematodes: Ostertagia spp., Teladorsagia spp., Haemonchus spp., Trichostrongylus spp., Cooperia spp., Oesophagostomum spp., Nematodirus spp., Strongyloides spp., Bunostomum spp., Toxocara spp. and Trichuris spp. and Chabertia spp.

Lungworms: Dictyocaulus spp. and Protostrongylus spp.

Eyeworm: Thelazia spp.

Lice: Linognathus spp. and Hematopinus spp. and Solenoptes spp.

Mites: Sarcoptes spp. and Psoroptes spp.

Oestrid larvae: Hypoderma bovis, Hyporderma lineatum and Oestrus ovis

Mechanism of action:

Closantel is a synthetic antiparasitic agent which is highly effective against liver fluke, bloodsucking nematodes and larval stages of some arthropods in sheep and cattle. Closantel decouples the mitochondrial oxidative phosphorylation, which leads to the inhibition of ATP synthesis. This causes a significant change in energy metabolism, leading to the death of the parasite.

Ivermectin is a macrocyclic lactone anthelmintic. It enhances the release of GABA at presynaptic neurons. GABA acts as an inhibitory neurotransmitter and blocks the post-synaptic stimulation of the adjacent neuron in nematodes or the muscle fiber in arthropods. By stimulating the release of GABA and/or producing a slow and irreversible increase in permeability of glutamate-gated chloride channels (GluCl) to chloride ions and hyperpolarization of nerve cells, ivermectin causes flaccid paralysis of the parasite and eventual death. Cestodes and trematodes do not use GABA as a peripheral neurotransmitter, thus ivermectin is ineffective against these parasites.

Dosage & Administration:

1 ml/25 kg B.W. by SC administration

Withdrawal times:

Meat

Cattle: 49 days after the last treatment

Sheep: 28 days after the last treatment

Contra indications:

Do not use in case of hypersensitivity to the active ingredients or any of the excipients.
Do not use for IV or IM administration.
Do not use in cattle or ewes produce milk for human consumption, even in the dry period.

Do not administer concomitantly with chlorinated compounds (pesticide).

Dispose of unused products and containers by incineration or in approved-landfills.

Ivermectin is very toxic for aquatic organisms and may accumulate in sediments.

Caution:

Do not administer more than 10 ml per injection site.

Keep out of reach and sight of children.

Use only under the prescription of a veterinarian.

In use stability:

28 days after first needle insertion

Storage:

Do not store above 25°C, keep away from light and freezing.

Packing:

50 ml vial in a box

For veterinary use only

Bottom of Form