Bayoxy^® 20% LA

Sterile Injectable Solution

Therapeutically classification: Antibiotic

Composition: Each ml contains:

Oxytetracycline dihydrate             200 mg

Target species: Cattle, Sheep, Goats

Indications: Bayoxy^® 20% LA is used for the treatment of several systemic and local infections in cattle, sheep and goats such as shipping fever, infectious gastroenteritis, acute mastitis, metritis, theileriosis, leptospirosis, actinobacillosis, black leg, bovine infectious keratoconjunctivitis, foot rot, enzootic abortion in ewes and also in prophylactic treatment of post-surgery and post parturition infections.

Mechanism of action: Oxytetracycline is a broad-spectrum bacteriostatic antibiotic. It has activity against most gram-negative and gram-positive bacteria such as Mycoplasma spp., Spirochetes, Chlamydia spp., and Rickettsias. Tetracyclines generally inhibit protein synthesis by binding to 30S ribosomal subunits of susceptible microorganisms, thereby prevent binding of aminoacyl transfer-RNA to those ribosomes. Tetracyclines also are believed to reversibly bind to 50S ribosomal subunits and additionally alter cytoplasmic membrane permeability in susceptible organisms. In high concentrations, tetracyclines can also inhibit protein synthesis by mammalian cells.

Administration & Dosage:

For long acting effect, the product is given by deep IM injection at a rate of 20 mg/kg B.W. (1 ml/10 kg B.W.). For slow IV administration in cattle, which achieves low volume injection but no Long-acting effect, a dose of 10 mg/kg B.W. (0.5 ml/10 kg B.W.) is recommended. This may be followed 24 hours later by a single IM injection at the 1 ml/10 kg B.W. dose.

In lambs for the treatment of tick pyaemia and as an aid in the treatment of tick-borne fever, a 2 ml dose is recommended per lamb by IM injection.

 Withdrawal time:

Meat: 21 days after the last treatment

Cow milk: 7 days after the last treatment

Contra-indications:

Do not use in lactating ewes producing milk for human consumption.

Do not administer to animals hypersensitive to tetracyclines.

Do not use with penicillins, cephalosporins and other bactericidal agents.

Do not use in horses, dogs and cats.

Do not administer to animals with sever impaired renal and/or liver function.

Do not dilute this product.

Caution:

Do not inject more than 10 ml in cattle and more than 5 ml in sheep and goats in one site.

Administer with extreme caution during the second half of pregnancy because of its effects on fetus (embryo osteogenesis disorders and discoloration of teeth).

Keep out of reach and sight of children.

Use only under the prescription of a veterinarian.

Storage:

Do not store above 25°C, keep away from light and freezing.

In use stability:

14 days after first needle insertion

Packing:

50 ml vial in a box

For veterinary use only