Bay Dorectin ^® 0.5%

Doramectin

Pour-on solution

Therapeutic classification: Antiparasite

Composition: Each ml contains:

Doramectin

5

mg

Target species: Cattle

Indications:

Bay Dorectin^® 0.5% is used for treatment of:

Gastrointestinal roundworms (adults and fourth stage larvae): Ostertagia ostertagi (inc. inhibited larvae), Haemonchus placei, Trichostrongylus axei, Cooperia oncophora, Cooperia punctate, Bunostomum phlebotomum^, Oesophagostomum radiatum and Trichuris spp.

Lungworms (adults and fourth stage larvae): Dictyocaulus viviparus

Eyeworms (adults): Thelazia spp.

Warbles (parasitic stages): Hypoderma bovis and Hypoderma lineatum

Biting lice: Damalinia (Bovicola) bovis

Sucking lice: Haematopinus eurystemus, Linognathus vituli and Solenopotes capillatus

Mange mites: Psoroptes bovis, Sarcoptes scabiei and Chorioptes bovis

Horn fly: Haematobia irritans

Mechanism of action:

Doramectin is a macrocyclic lactone anthelmintic that enhances the release of GABA at presynaptic neurons. GABA acts as an inhibitory neurotransmitter and blocks the post-synaptic stimulation of the adjacent neuron in nematodes or the muscle fiber in arthropods. By stimulating the release of GABA and/or producing a slow and irreversible increase in permeability of glutamate-gated chloride channels (GluCl) to chloride ions and hyperpolarization of nerve cells, doramectin causes flaccid paralysis of the parasite and eventual death. Cestodes and tapeworms do not use GABA as a peripheral neurotransmitter then doramectin is ineffective against these parasites.

Dosage & Administration:

A single treatment of 1 ml (5 mg)/10 kg B.W., applied topically along the mid-line of the back in a narrow strip between the withers and tailhead.

Withdrawal time:

Meat: 35 days

Contra-indications:

Do not use in cattle that produce milk for human consumption.

Doramectin is very toxic to aquatic organisms and may accumulate in sediments. The risk to aquatic ecosystem will be reduced by keeping treated cattle away from water bodies for two to five weeks after treatment.

Caution:

For external use only

Should be used within 30 days after opening the seal.

Do not smoke or eat while handling the product.

Wash hands after use.

Keep out of reach and sight of children.

Use only under the prescription of a veterinarian.

Storage:

Do not store above 25 °C, keep away from light and freezing.

Packing:

250 mL HDPE bottle in a box

For veterinary use only