Aflamectin^® 1%

Ivermectin

Sterile injectable solution

Therapeutically classification: Internal and external anti-parasite

Composition: Each ml contains:

Ivermectin             10 mg

Target species: Horses, Camels, Cattle, Sheep, Dogs and Cats

Indications:

Ivermectin is a broad-spectrum anti-parasitic agent. It is indicated for the treatment and control of internal and external parasites in different species as:

Cattle and Sheep:

Gastrointestinal nematode species: Ostertagia spp., Haemonchus spp., Cooperia spp., Nematodirus spp., Trichostrongylus spp., Bunostomum spp., Trichuris spp., Strongyloides spp., Oesophagostomum spp. and Chabertia ovina

Lung worms: Dictyocaulus spp.

Mites: Sarcoptes bovis and Psoroptes ovis

Sucking lice: Linognathus vituli, L. pedalis, and Hematopinus eurysternus

Oestrid larvae: Hypoderma bovis, Hypoderma lineatum and Oestrus ovis

Horses: Parascaris equorum, Oxyuris equi, Draschia megastoma, trichostrongylus axei, Large and small Strongyles, Microfiller of Onchocerca spp., Habronema spp. and Gasterophilus spp.

Camels: Nematodes and mange mites

Dogs: Heartworm (prevention and treatment), mites, nematodes, roundworms, hookworms and whipworms

Cats: Ear mites, fleas and hookworms

Mechanism of action:

Ivermectin is a macrocyclic lactone anthelmintic that enhances the release of GABA at presynaptic neurons. GABA acts as an inhibitory neurotransmitter and blocks the post-synaptic stimulation of the adjacent neuron in nematodes or the muscle fiber in arthropods. By stimulating the release of GABA and/or producing a slow and irreversible increase in permeability of glutamate-gated chloride channels (GluCl) to chloride ions and hyperpolarization of nerve cells, ivermectin causes flaccid paralysis of the parasite and eventual death. Cestodes and tapeworms do not use GABA as a peripheral neurotransmitter then ivermectin is ineffective against these parasites.

Dosage and Administration:

The drug dosage is 200 μg/kg B.W. or 0.5 ml/25 kg B.W.

Horses: By IM administration only.

Cattle, Camels and Sheep: By SC administration.

Dogs and Cats: By SC injection in loose skin in front of or behind of the shoulder.

For prevention of heartworm in dogs 6 µg/kg B.W., monthly by SC administration

Withdrawal time:

Meat: 21 days after the last treatment

Milk: 28 days after the last treatment

Contra-indications:

Do not administer intravenously.

Do not use in foals less than 4 months old.

Do not use in animals less than 6 weeks old.

Use in Collie-breeds with caution and less than routine dose. Observe this breed for at least 8 hours after administration.

Dispose of unused products and containers by incineration or in approved-landfills. Ivermectin may adversely affect fish or other waterborne organisms if disposed in water.

Do not administer with drugs that could potentially increase the penetration of ivermectin across the blood–brain barrier. Such drugs include ketoconazole, itraconazole, cyclosporine and calcium-channel blockers.

Caution:

Keep out of reach and sight of children.

Use only under the prescription of a veterinarian.

In use stability:

21 days after first needle insertion

Storage:

Do not store above 25°C, keep away from light and freezing

Packing:

50 ml vial in a box

For veterinary use only